Cannabinoid Receptor
Cannabinoid Receptor
Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.
Cannabinoid Receptor Isoform Specific Products
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Cannabinoid Receptor Inhibitors
(38)
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Cannabinoid Receptor Activators
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Cannabinoid Receptor Modulators
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Cannabinoid Receptor Chemical
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Cannabinoid Receptor Inducer
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Cannabinoid Receptor Degrader
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Cannabinoid Receptor Controls
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Cannabinoid Receptor Ligands
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Cannabinoid Receptor Related Products (450)
Related Products (450)
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Antibodies (1)
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Cannabinoid Receptor Isoform Comparison
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Linderane (Standard)
0 ImagesCat. No.: HY-N0688RCAS No.: 13476-25-0Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety.
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8(S)-Hydroxy-9(R)-hexahydrocannabinol
0 ImagesCat. No.: HY-168788CAS No.: 74509-39-08(S)-Hydroxy-9(R)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
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Bzo-poxizid
0 ImagesCat. No.: HY-W783639CAS No.: 1048973-64-3Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance.
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ADB-IATA
0 ImagesCat. No.: HY-175143Synonyms: ADB-IACAADB-IATA (ADB-IACA) is a synthetic cannabinoid receptor agonist (SCRA). ADB-IATA belongs to the category of psychoactive substances.
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O-1663
0 ImagesCat. No.: HY-114802CAS No.: 468083-84-3O-1663 is a full agonist of cannabinoid receptor 2 (CB2 receptor). O-1663 stimulates the production of ROS, downregulates Id1, and induces autophagy and apoptosis in breast cancer cells. O-1663 inhibits the proliferation, invasion and metastasis of breast cancer cells. O-1663 prolongs the survival of models with advanced metastatic breast cancer. O-1663 can be used for the research of metastatic breast cancer.
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(±)-9-Nor-9β-hydroxy Hexahydrocannabinol
0 ImagesCat. No.: HY-168793CAS No.: 56469-25-1(±)-9-Nor-9β-hydroxy Hexahydrocannabinol is structurally similar to known synthetic cannabinoids.
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NAPIE
0 ImagesCat. No.: HY-158836CAS No.: 2748289-69-0NAPIE is structurally similar to known synthetic cannabinoids.
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CB2 receptor antagonist 4
0 ImagesCat. No.: HY-155481ACB2 receptor antagonist 4 (compound (R)-1) is a CB2R-selective inverse agonist with a Kd value of 39 nM.
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2-(1-(4-Fluorobenzyl)-1H-indol-3-yl)acetic acid
0 ImagesCat. No.: HY-W030120CAS No.: 176204-51-62-(1-(4-Fluorobenzyl)-1H-indol-3-yl)acetic acid is structurally similar to cannabinoid.
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PSB-SB1202
0 ImagesPSB-SB1202 (Compound 21a) is a phenyl coumarin compound. PSB-SB1202 is a CB1/CB2 agonist with EC50 values of 56 and 14 nM, and Ki values of 32 and 49 nM, respectively.
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exo-Tetrahydrocannabivarin
0 ImagesCat. No.: HY-168368CAS No.: 137008-69-6exo-Tetrahydrocannabivarin (Compound 12) is a Δ9,11-THC analogue. exo-Tetrahydrocannabivarin weakly binds to cannabinoid receptors (CB) (IC50: 1.4 μM). exo-Tetrahydrocannabivarin is active on both motor and analgesic aspects in mice.
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Giminabant
0 ImagesCat. No.: HY-111195CAS No.: 890033-57-5Giminabant is a cannabinoid receptor antagonist for veterinary use. Giminabant can be used for the research of metabolic diseases and addiction-related disorders.
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Δ8-THCPA-A
0 ImagesCat. No.: HY-170696CAS No.: 2897582-89-5Synonyms: Δ8-Tetrahydrocannabiphorolic acidΔ8-THCPA-A (Δ8-Tetrahydrocannabiphorolic acid) is structurally similar to known phytocannabinoids.
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Carmagerol
0 ImagesCat. No.: HY-170703CAS No.: 140396-81-2Carmagerol is a phytocannabinoid metabolite.
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8(R)-Hydroxy-9(R)-hexahydrocannabinol
0 ImagesCat. No.: HY-168789CAS No.: 42793-11-38(R)-Hydroxy-9(R)-hexahydrocannabinol, a phytocannabinoid compound, is a metabolite of 9(R)-Hexahydrocannabinol.
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(±)-8'-Hydroxy cannabichromene
0 ImagesCat. No.: HY-170039CAS No.: 132032-41-88'-Hydroxy cannabichromene is a phytocannabinoid metabolite.
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Rimonabant Hydrochloride (Standard)
0 ImagesSynonyms: SR 141716A Hydrochloride (Standard)Rimonabant (Hydrochloride) (Standard) is the analytical standard of Rimonabant (Hydrochloride). This product is intended for research and analytical applications. Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
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5-Fluoro PB-22 N-(2-fluoropentyl) isomer
0 ImagesCat. No.: HY-172043CAS No.: 2365471-10-75-Fluoro PB-22 N-(2-fluoropentyl) isomer is a derivative of cannabinoid.
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Tetrahydrocannabiphorol
0 ImagesCat. No.: HY-W775348CAS No.: 54763-99-4Synonyms: THCPTetrahydrocannabiphorol (THCP) is a phytocannabinoid.
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Rimonabant (Standard)
0 ImagesSynonyms: SR141716 (Standard)Rimonabant (Standard) is the analytical standard of Rimonabant. This product is intended for research and analytical applications. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
